Testing pooled samples enables universal screening of congenital cytomegalovirus infection - Nature.com

The implementation of PCR tests of pooled saliva samples for universal screening of congenital cytomegalovirus infection was assessed in 15,805 neonates over 13 months. This extensive analysis revealed the high feasibility and empirical efficiency of the pooled testing approach, which had a clinically insignificant loss of sensitivity.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Newborn cCMV screening scheme and performance rates.

References

  1. Rawlinson, W. D. et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect. Dis. 17, e177–e188 (2017). A review article on consensus recommendations for the prevention, diagnosis and therapy of cCMV infection.

    Article  PubMed  Google Scholar 

  2. Pinninti, S. & Boppana, S. Congenital cytomegalovirus infection diagnostics and management. Curr. Opin. Infect. Dis. 35, 436–441 (2022). A review article on developments in the diagnosis and management of children with cCMV.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Pesch, M. H. & Schleiss, M. R. Emerging concepts in congenital cytomegalovirus. Pediatrics. 150, e2021055896 (2022). A review article on the epidemiology, long-term sequelae, screening approaches and areas for future investigation of cCMV.

    Article  PubMed  Google Scholar 

  4. Fowler, K. B. et al. A targeted approach for congenital cytomegalovirus screening within newborn hearing screening. Pediatrics 139, e20162128 (2017). This paper reports that 43% of infants with (or at risk for late-onset) CMV-related hearing loss were not identified by targeted cCMV screening.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Barak, N. et al. Lessons from applied large-scale pooling of 133,816 SARS-CoV-2 RT–PCR tests. Sci. Transl. Med. 13, eabf2823 (2021). This paper reports on our implementation of a sample-pooling pipeline for the efficient detection of SARS-CoV-2.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Additional information

Publisher's note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Merav, L. et al. Implementation of pooled saliva tests for universal screening of cCMV infection. Nat. Med. https://doi.org/10.1038/s41591-024-02873-3 (2024).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Testing pooled samples enables universal screening of congenital cytomegalovirus infection. Nat Med (2024). https://doi.org/10.1038/s41591-024-02901-2

Download citation

  • Published:

  • DOI: https://doi.org/10.1038/s41591-024-02901-2

Adblock test

Comments

Popular posts from this blog

What does herpes look like: Pictures, treatment, and prevention - Medical News Today